Possible Interaction: Quercetin and Iron, Dietary

“ Quercetin attenuated the abnormity induced by ethanol and/or iron.”

“In this study, HUVECs was treated with 50 μM … 20 μM Que for 48 h. We found that Que attenuated the … by iron , as evidenced by decreased ROS generation, increased DDAHⅡexpression and activity, reduced ADMA level, … content and p-eNOS/eNOS ratio, and eventually caused a decrease in apoptosis.”

“ Quercetin , rutin and (+)catechin exhibited strong antioxidant properties toward Fe , but this effect was decreased with respect to Zn ions.”

“Consistent with this, cellular induction of HIF-1α by quercetin was abolished by pretreatment with iron.”

“HPH inhibition by quercetin was neutralized significantly by an elevated dose of iron.”

“Our data demonstrate that quercetin depletes intracellular calcein-chelatable iron and that supplying additional iron from extracellular or intracellular pools abrogates the induction of HIF-1alpha by quercetin.”

“We propose that quercetin stabilises HIF-1alpha and inhibits cell proliferation predominantly by decreasing the concentration of intracellular iron through chelation.”

“Supplementation with quercetin significantly decreased liver Fe , V, and Se content, which was more noticeable in the Wistar rats than in the Z rats.”

“Meanwhile, quercetin lowered the iron level particularly in the islet in T2DM mice.”

“Besides, quercetin decreased malondialdehyde levels and histological damages in the liver and kidney of Fe group as compared with sham, DMSO and Quer groups.”

“In addition, quercetin upregulated Nrf2/HO-1 expression and modulated the labile iron pool in infected macrophages, culminating in a depletion of available iron for L. braziliensis replication.”

“These findings show that QCT has a dual effect; at low doses it ameliorates the oxidative damage produced by iron , and it is genotoxic and cytotoxic at a higher dose.”