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Last Updated: 8 months ago

Possible Interaction: Quercetin and Irinotecan

supplement:

Quercetin

Research Papers that Mention the Interaction

There is mounting evidence to suggest that quercetin has potential anticancer effects and appears to interact synergistically when used in combination with approved chemotherapeutic agents such as irinotecan and cisplatin.
Drug Delivery and Translational Research  •  2019  |  View Paper
Furthermore, the concentration of angiogenesis-associated factors (vascular endothelial growth factor (VEGF)-A and VEGF-receptor 2) and percentage of Tie2-expressing monocytes was significantly down-regulated in combined treatments with quercetin and irinotecan.
In the AGS xenograft mouse model, gene expression of cyclooxygenase-2 and epithelial-mesenchymal transition-related markers, such as Twist1 and ITGβ6, were lower in combined treatments with quercetin and low-dose irinotecan than high-dose irinotecan alone.
The Journal of nutritional biochemistry  •  2018  |  View Paper
Quercetin pre-treatment resulted in increased irinotecan C(max) and area under curve (AUC) with a concomitant decrease in t(max), plasma clearance and volume of distribution (p<0.05).
The amounts of irinotecan and SN-38 eliminated in bile in control rats, is reduced to almost half when treated with quercetin.
Life sciences  •  2008  |  View Paper