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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Quercetin
drug:
Irinotecan
Research Papers that Mention the Interaction
“There is mounting evidence to suggest that quercetin has potential anticancer effects and appears to interact synergistically when used in combination with approved chemotherapeutic agents such as irinotecan and cisplatin.”
Characterization of a liposomal copper(II)-quercetin formulation suitable for parenteral use“Furthermore, the concentration of angiogenesis-associated factors (vascular endothelial growth factor (VEGF)-A and VEGF-receptor 2) and percentage of Tie2-expressing monocytes was significantly down-regulated in combined treatments with quercetin and irinotecan.”
“In the AGS xenograft mouse model, gene expression of cyclooxygenase-2 and epithelial-mesenchymal transition-related markers, such as Twist1 and ITGβ6, were lower in combined treatments with quercetin and low-dose irinotecan than high-dose irinotecan alone.”
“ Quercetin pre-treatment resulted in increased irinotecan C(max) and area under curve (AUC) with a concomitant decrease in t(max), plasma clearance and volume of distribution (p<0.05).”
“The amounts of irinotecan and SN-38 eliminated in bile in control rats, is reduced to almost half when treated with quercetin.”
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