Possible Interaction: Quercetin and Interleukin-10

“CONCLUSIONS The present study suggests that qu rcetin am eliorates EAM, at least in part, by interfering production of proinflammatory (TNF-α and IL-17) and/or anti-inflammatory (IL- 10) c ytokines.”

“Under the influence of quercetin , levels of IL-1β and TNF-α were reduced and IL-10 levels tended to decrease.”

“Muscle NF-kappaB did not increase postexercise and did not differ between Q and … postexercise but did not differ between Q and P. In summary, 1 g/day quercetin supplementation by trained cyclists over … of leukocyte IL-8 and IL-10 mRNA, indicating that elevated … within the blood compartment.”

“ Quercetin treatment increased the expressions of IL-10 , VEGF, TGF-β1, CD31, α-SMA, PCNA, and GAP-43, and decreased the expressions of TNF-α.”

“The expression of IL-10 reporter was inhibited by quercetin , xanthones and dexamethasone in LPS-induced RAW 264.7 cells.”

“In conclusion, quercetin can preserve the function of the liver in acute alcoholic injury by upregulating the expression of IL-10 and HO-1 and thus inhibiting NLRP3 inflammasome activation and inflammatory factor secretion.”

“Meanwhile, quercetin also upregulated the anti-inflammatory factor IL-10 , while it was found uncorrelated with HO-1 expression.”

“ Quercetin also inhibited secretion of the inflammatory cytokines IL-1β and IL-6 and stimulated that of IL-10 , an antiinflammatory cytokine.”

“ Quercetin markedly rescued lethality, improved survival time, and inhibited serum necrosis factor α, interleukin 1β, and interleukin 6, and nitric oxide (NO), and increased IL-10 secretion.”

“ Quercetin treatment also attenuated the expression of both TNF-alpha (TNF-α) and interleukin-10 (IL-10) and lowered the serum levels of inflammatory cytokine (P < 0.05).”

“We also found that luteolin and quercetin are able to stimulate the expression of the anti-inflammatory cytokine IL-10 at low concentrations (<50microM).”