Possible Interaction: Quercetin and Genistein

“Prooxidant effect of genistein –daidzein mixture’, at their concentrations reflecting the real life, was suppressed by addition of quercetin to the mixture.”

“These data suggest that prenatal exposure to both genistein and quercetin supplements could increase the risk on Mll rearrangements especially in the presence of compromised DNA repair.”

“Furthermore, resveratrol in combination with genistein and quercetin synergistically decreased adipogenesis in murine and human adipocytes.”

“ Genistein acts synergistically with drugs such as tamoxifen, cisplatin, 1,3-bis 2-chloroethyl-1-nitrosourea (BCNU), dexamethasone, daunorubicin and tiazofurin, and with bioflavonoid food supplements such as quercetin , green-tea catechins and black-tea thearubigins.”

“Current studies reveal that tiazofurin with quercetin, tiazofurin with genistein, and quercetin with genistein were synergistic in killing human cancer cells and in reducing signal transduction activity.”

“ Quercetin and genistein , which attack different targets and different phases of the cell cycle, proved to be synergistic in OVCAR-5 cells.”

“Significantly elevated caspase-3 activity was noted after treatment with genistein (10−9–10−7 mol/l), as well as with resveratrol and quercetin (10−9–10−5 mol/l).”

“The transcellular transport of genistein was saturable and temperature‐dependent, and was inhibited by other flavonoids such as rutin, quercetin , (+)‐catechin and (−)‐epicatechin.”

“Combinations of tiazofurin with quercetin, tiazofurin with genistein, and quercetin with genistein yielded a synergistic kill of ovarian cancer cells.”

“The synergistic action of quercetin and genistein may be of interest in clinical treatment of human ovarian carcinoma.”