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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Quercetin
drug:
Fexofenadine
Research Papers that Mention the Interaction
“Although the oral clearance of fexofenadine was decreased significantly by 37% after quercetin treatment (61.4 versus 38.7 L/h, P < 0.001), no differences in the renal clearance and half-life were observed between placebo and quercetin phases.”
“ConclusionThe results of the present study showed that short-term use of quercetin elevated the plasma concentrations of fexofenadine , probably by the inhibition of P-gp-mediated efflux in humans.”
“ResultsThe mean plasma concentrations of fexofenadine were significantly increased after quercetin treatment compared to those of the placebo phase.”
“The area under … (AUC) of plasma fexofenadine … quercetin (2,005.3 versus 3,098.6 ng·h/mL, P < 0.001) and similarly the maximum plasma concentration (Cmax) during … elevated by 68% compared to that of the placebo phase (295.3 versus 480.3 ng/mL, P = 0.006).”
Short-term effect of quercetin on the pharmacokinetics of fexofenadine, a substrate of P-glycoprotein, in healthy volunteers
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