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Discover Supplement-Drug Interactions

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Last Updated: 8 months ago

Possible Interaction: Quercetin and Fexofenadine



Research Papers that Mention the Interaction

Although the oral clearance of fexofenadine was decreased significantly by 37% after quercetin treatment (61.4 versus 38.7 L/h, P < 0.001), no differences in the renal clearance and half-life were observed between placebo and quercetin phases.
ConclusionThe results of the present study showed that short-term use of quercetin elevated the plasma concentrations of fexofenadine , probably by the inhibition of P-gp-mediated efflux in humans.
ResultsThe mean plasma concentrations of fexofenadine were significantly increased after quercetin treatment compared to those of the placebo phase.
The area under … (AUC) of plasma fexofenadine … quercetin (2,005.3 versus 3,098.6 ng·h/mL, P < 0.001) and similarly the maximum plasma concentration (Cmax) during … elevated by 68% compared to that of the placebo phase (295.3 versus 480.3 ng/mL, P = 0.006).
European Journal of Clinical Pharmacology  •  2009  |  View Paper