Possible Interaction: Quercetin and Epigallocatechin Gallate

“ Quercetin increased the cellular absorption of epigallocatechin gallate (EGCG) four-fold in A549 cells with a decreased methylation rate from 63 to 19%, 2-fold in 786-O cells with a decreased methylation from 97% to 56%, while no significant effect was observed in HepG2 cells.”

“The coadministration of quercetin and EGCG significantly increased the BCA area under the plasma concentration vs time curve (AUC) in rats, after both iv and oral administration of BCA.”

“Furthermore, combination of quercetin with EGCG had synergistic inhibitory effects on self‐renewal capacity of CSCs through attenuation of TCF/LEF and Gli activities.”

“Colony survival assays demonstrate that treatment of breast cancer cells with green tea (−)‐epigallocatechin gallate (EGCG), which binds to the ATP‐binding domain of GRP78 and blocks its protective function, synergistically promoted quercetin‐induced cell death.”

“These findings suggest that EGCG and quercetin exert synergistic anti-diabetes effect, possibly via decreasing the expression of miR-16-5p that targets directly BCL-2.”

“The combination of quercetin nanoparticles and EGCG suggested the additive effect of antioxidant activity.”

“Furthermore, all FEQ facilitated the stability of EGCG and quercetin molecules relative to free ones, and simultaneous co-encapsulation of EGCG and quercetin could significantly improve the quercetin stability as compared with that of free one and the quercetin-loaded ferritin (p<0.05), respectively.”

“These results demonstrated that co-encapsulation of EGCG and quercetin enhances their effectiveness.”

“Results showed that kaempferol, quercetin , and myricetin accelerated the oxidation of EGCG and made the model solution browning.”

“Interestingly, quercetin synergizes with EGCG in inhibiting the self-renewal properties of prostate CSCs, inducing apoptosis, and blocking CSC's migration and invasion.”