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Last Updated: 8 months ago

Possible Interaction: Quercetin and Epigallocatechin Gallate



Research Papers that Mention the Interaction

Quercetin increased the cellular absorption of epigallocatechin gallate (EGCG) four-fold in A549 cells with a decreased methylation rate from 63 to 19%, 2-fold in 786-O cells with a decreased methylation from 97% to 56%, while no significant effect was observed in HepG2 cells.
Food & function  •  2012  |  View Paper
The coadministration of quercetin and EGCG significantly increased the BCA area under the plasma concentration vs time curve (AUC) in rats, after both iv and oral administration of BCA.
Molecular pharmaceutics  •  2007  |  View Paper
Furthermore, combination of quercetin with EGCG had synergistic inhibitory effects on self‐renewal capacity of CSCs through attenuation of TCF/LEF and Gli activities.
International journal of cancer  •  2012  |  View Paper
Colony survival assays demonstrate that treatment of breast cancer cells with green tea (−)‐epigallocatechin gallate (EGCG), which binds to the ATP‐binding domain of GRP78 and blocks its protective function, synergistically promoted quercetin‐induced cell death.
Journal of cellular and molecular medicine  •  2009  |  View Paper
These findings suggest that EGCG and quercetin exert synergistic anti-diabetes effect, possibly via decreasing the expression of miR-16-5p that targets directly BCL-2.
The Journal of nutritional biochemistry  •  2021  |  View Paper
Furthermore, all FEQ facilitated the stability of EGCG and quercetin molecules relative to free ones, and simultaneous co-encapsulation of EGCG and quercetin could significantly improve the quercetin stability as compared with that of free one and the quercetin-loaded ferritin (p<0.05), respectively.
Journal of agricultural and food chemistry  •  2020  |  View Paper
These results demonstrated that co-encapsulation of EGCG and quercetin enhances their effectiveness.
Journal of food science  •  2019  |  View Paper
Results showed that kaempferol, quercetin , and myricetin accelerated the oxidation of EGCG and made the model solution browning.
Journal of Food Science and Technology  •  2017  |  View Paper
Interestingly, quercetin synergizes with EGCG in inhibiting the self-renewal properties of prostate CSCs, inducing apoptosis, and blocking CSC's migration and invasion.
Journal of molecular signaling  •  2010  |  View Paper