Possible Interaction: Quercetin and Docetaxel

“Although single docetaxel application had little effect on docetaxel-resistant cells, combining docetaxel with quercetin was significantly effective.”

“As shown by in-vivo study, xenograft tumors treated by docetaxel with quercetin had poorest growth.”

“Here, we confirmed that Lef1 inhibition, especially on treatment with the small molecule quercetin , decreased the expression of Lef1 and resensitized cells to docetaxel.”

“In comparison to oral docetaxel alone (… mg/kg), the bioavailability of docetaxel could be significantly enhanced by 1.6– 2.4‐fold via oral co‐administration with various flavonoids (apigenin, naringenin, baicalein, quercetin and myricetin) at a dosage of 10 mg/kg, and myricetin showed the highest bioavailability improvement.”

“The concomitant use of docetaxel and quercetin leads to the cell growth inhibition associated with the induction of apoptosis and inhibition of cell survival.”

“The results showed that the single-agent treatment … cells at 48 h. Furthermore, the combination of docetaxel (… quercetin (95 μM) displayed the greatest synergistic effects with a combination index value of 0.76 accompanied … decrease in the levels of BCL2, pERK1/2, AKT, and STAT3 proteins (P < 0.05).”

“By contrast, a significant interaction caused by quercetin (100 mg/kg) was observed in the absorption of docetaxel.”