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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
Research Papers that Mention the Interaction
“We previously demonstrated that the combination of dasatinib and the flavonoid quercetin is a potent senolytic improving numerous age-related conditions including frailty, osteoporosis and cardiovascular disease.”
Fisetin is a senotherapeutic that extends health and lifespan“For example, the combination of 2 drugs, Dasatinib and Quercetin , was shown to exert killing potential of senescent preadipocyte and endothelial cells.”
“Fetal ASM exposed to 40% O2 for 7 days exhibited elevated levels of senescence-associated markers … p16, p21 and p-p53, and the DNA damage marker p-γH2A.X. The combination of dasatinib … quercetin , compounds known to eliminate senescent cells (senolytics), reduced …, and p-γH2A.X positive ASM cells.”
“We investigated effects of aging and the senolytic drug combination of dasatinib plus quercetin (D+Q) on uterine fibrosis.”
Dasatinib plus quercetin prevents uterine age-related dysfunction and fibrosis in mice“In addition, Que (10 mg/kg) in combination with dasatinib (5 mg/kg) has been reported to reduce hepatic steatosis (Ogrodnik et al., 2017).”
“Therefore, high-dose Que and extra side effects of dasatinib would hamper potential clinical applications of Que in geriatric medicines.”
“The senolytic cocktail, dasatinib plus quercetin , which causes selective elimination of senescent cells, decreased the number of naturally occurring senescent cells and their secretion of frailty-related proinflammatory cytokines in explants of human adipose tissue.”
“The combination of dasatinib and quercetin was effective in eliminating senescent MEFs.”
“Previous studies showed that whereas a combination of the senolytic drugs dasatinib and quercetin (D + Q) reduced NAFLD in mice, D + Q lacked efficacy in removing doxorubicin-induced β-gal-positive senescent cells in human HCC xenografted mice.”
Mild exacerbation of obesity- and age-dependent liver disease progression by senolytic cocktail dasatinib + quercetin“The senolytic drug combination, Dasatinib plus Quercetin (D+Q), is known to reduce senescent cell abundance in aged mice.”
“Treatment with a combination of Que and Das synergistically increased the expression of decidualization markers and senescence markers compared with treatment with Que or Das alone.”
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