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“Formation of 8-oxodG by quercetin increased extensively in the presence of Cu(II) , whereas 8-oxodG formation by kaempferol or luteolin increased only slightly.”
“ Quercetin induced extensive DNA damage via reacting with Cu(II) , but kaempferol and luteolin induced little DNA damage even in the presence of Cu(II).”
“We find that quercetin can block ROS generation through Fenton reaction to produce hydroxyl radicals by chelating with transition metal ions such as Cu2+.”
“As for the central ion (M2+), when chelated with quercetin to form the complex, the stability of the complex decreased in the following order: Cu2+ > Ni2+ > Co2+ > Fe2+ > Zn2+.”
“The reaction of quercetin with Cu(II) resulted in the formation of 1:1 metal–ligand complex (λmax = 436 nm) through the carbonyl oxygen and 3-OH group in C ring.”
“The present work first observed that there was an intermediate product formed during the complex formation of quercetin reacting with Cu2+ and the absorption band of the final complex was centered at 296 nm.”