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Discover Supplement-Drug Interactions
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Last Updated: 4 years ago
supplement:
Quercetin
drug:
Bortezomib
Research Papers that Mention the Interaction
“Moreover, quercetin induced a prosurvival autophagy in these cells and increased the cytotoxic effect of bortezomib , a proteasomal inhibitor, against them.”
Quercetin induces apoptosis and autophagy in primary effusion lymphoma cells by inhibiting PI3K/AKT/mTOR and STAT3 signaling pathways.“This inhibitory effect was associated with chemical reactions between quercetin and the boronic acid group, -RB(OH)2, in bortezomib.”
“A DNA ladder assay also confirmed the inhibitory effect of quercetin on the apoptosis-inducing effect of bortezomib.”
“Quantitation of cell viability also indicated that quercetin interfered with the cytotoxic effects of bortezomib.”
“Unexpectedly, such morphological changes were not observed in cells treated with 20 µM quercetin alone, nor in cells treated with bortezomib + quercetin, indicating that quercetin inhibited the cytotoxic effects of bortezomib.”
Combined effects of the proteasome inhibitor bortezomib and Hsp70 inhibitors on the B16F10 melanoma cell line.
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