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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“Cytochrome P450 inhibitors (econazole, proadifen, quercetin ) decreased ascorbate consumption and the gulonolactone or ascorbate‐stimulated thiol oxidation.”
Ascorbate‐mediated electron transfer in protein thiol oxidation in the endoplasmic reticulum“This neuroprotection apparently relies on the inhibition of oxidative stress, because ascorbate prevented the pro‐oxidant action of the scavenging molecule quercetin , which occurred over the course of prolonged exposure, as is also seen with glutamate.”
“In a 10-day experiment, 40 microM quercetin stabilized by 1 mM ascorbate reduced Caco-2 differentiation up to 50% (p < 0.001).”
“The antioxidative function of quercetin was enhanced by ascorbate even under conditions in which ascorbate functioned as a prooxidant when it was added alone.”
“The enhancement is attributed to the functions of ascorbate to reduce the oxidized quercetin and of quercetin to inhibit ascorbate photooxidation.”
“ Ascorbate was oxidized by illumination in the presence of quercetin.”
“However, in the presence of 40 μM quercetin, ascorbate promoted the suppression.”
“In scavenging, quercetin was oxidized and the oxidation was suppressed by ascorbate.”
“It is suggested that the cooperation of quercetin with ascorbate in photohemolysis is due to reduction of oxidized quercetin by ascorbate regenerating the flavonol.”
“ Quercetin also significantly decreased ascorbate absorption in normal rats given ascorbate plus quercetin compared with rats given ascorbate alone.”
“ Quercetin was a reversible and non-competitive inhibitor of ascorbate transport; K i 17.8 μm.”
Flavonoid Inhibition of Sodium-dependent Vitamin C Transporter 1 (SVCT1) and Glucose Transporter Isoform 2 (GLUT2), Intestinal Transporters for Vitamin C and Glucose*“Inhibitors of ascorbate oxidation (proadifen, econazole or quercetin ) also effectively decreased the uptake of ascorbate.”
“The mutagenicity of quercetin was enhanced by the cytosolic fraction of liver extract (S100), or by ascorbate , and even more by the complete liver supernatant (S9) in the presence of cofactors (NADP and glucose-6-phosphate).”
“ Quercetin exhibited antiviral activity only when protected against oxidative degradation by ascorbate.”
Antiviral activity of flavones and potentiation by ascorbate.“ Ascorbate , superoxide dismutase, and, to a lesser extent, NADH and NADPH, all enhanced the mutagenic activity of quercetin in the absence of the mammalian-microsome (S9) system, but had no significant effect in the presence of the S9 mix.”
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