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Last Updated: 8 months ago

Possible Interaction: Quercetin and Ascorbate

supplement:

Quercetin

supplement:

Ascorbate

Research Papers that Mention the Interaction

Cytochrome P450 inhibitors (econazole, proadifen, quercetin ) decreased ascorbate consumption and the gulonolactone or ascorbate‐stimulated thiol oxidation.
FEBS letters  •  1999  |  View Paper
This neuroprotection apparently relies on the inhibition of oxidative stress, because ascorbate prevented the pro‐oxidant action of the scavenging molecule quercetin , which occurred over the course of prolonged exposure, as is also seen with glutamate.
Journal of neuroscience research  •  2013  |  View Paper
In a 10-day experiment, 40 microM quercetin stabilized by 1 mM ascorbate reduced Caco-2 differentiation up to 50% (p < 0.001).
Molecular nutrition & food research  •  2007  |  View Paper
The antioxidative function of quercetin was enhanced by ascorbate even under conditions in which ascorbate functioned as a prooxidant when it was added alone.
The enhancement is attributed to the functions of ascorbate to reduce the oxidized quercetin and of quercetin to inhibit ascorbate photooxidation.
Biochimica et biophysica acta  •  1991  |  View Paper
Ascorbate was oxidized by illumination in the presence of quercetin.
However, in the presence of 40 μM quercetin, ascorbate promoted the suppression.
In scavenging, quercetin was oxidized and the oxidation was suppressed by ascorbate.
It is suggested that the cooperation of quercetin with ascorbate in photohemolysis is due to reduction of oxidized quercetin by ascorbate regenerating the flavonol.
Photochemistry and photobiology  •  1988  |  View Paper
Quercetin also significantly decreased ascorbate absorption in normal rats given ascorbate plus quercetin compared with rats given ascorbate alone.
Quercetin was a reversible and non-competitive inhibitor of ascorbate transport; K i 17.8 μm.
The Journal of Biological Chemistry  •  2002  |  View Paper
Inhibitors of ascorbate oxidation (proadifen, econazole or quercetin ) also effectively decreased the uptake of ascorbate.
The Biochemical journal  •  2000  |  View Paper
The mutagenicity of quercetin was enhanced by the cytosolic fraction of liver extract (S100), or by ascorbate , and even more by the complete liver supernatant (S9) in the presence of cofactors (NADP and glucose-6-phosphate).
Mutation research  •  1990  |  View Paper
Quercetin exhibited antiviral activity only when protected against oxidative degradation by ascorbate.
The Journal of general virology  •  1988  |  View Paper
Ascorbate , superoxide dismutase, and, to a lesser extent, NADH and NADPH, all enhanced the mutagenic activity of quercetin in the absence of the mammalian-microsome (S9) system, but had no significant effect in the presence of the S9 mix.
Mutation research  •  1985  |  View Paper
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