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Discover Supplement-Drug Interactions

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Last Updated: 8 months ago

Possible Interaction: Pyrimethamine and Folate



Research Papers that Mention the Interaction

The use of the standard RPMI medium or RPMI medium containing low concentrations of folate and para-aminobenzoic acid increases the 50% inhibitory concentrations of cycloguanil and pyrimethamine , as compared with the use of folate- and para-aminobenzoic acid-free RPMI medium.
Bulletin de la Societe de pathologie exotique  •  1999  |  View Paper
By disturbing folate metabolism in this fungus, pyrimethamine can inhibit ergosterol production.
International journal of antimicrobial agents  •  2006  |  View Paper
Trimethoprim and pyrimethamine are weak competitive inhibitors of intestinal folate transport and folate absorption inhibition occurs at the site of membrane transport and appears to be unrelated to concurrent inhibition of DHFR activity in enterocytes.
Trimethoprim and pyrimethamine , inhibitors of dihydrofolate reductase (DHFR), cause folate deficiency in some patients.
The American journal of clinical nutrition  •  1987  |  View Paper
The binding of folate analogs including folate, dihydrofolate, methotrexate, trimethoprim and pyrimethamine induce large Cotton effects.
Biochimica et biophysica acta  •  1975  |  View Paper