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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Pyrimethamine
supplement:
Folate
Research Papers that Mention the Interaction
“The use of the standard RPMI medium or RPMI medium containing low concentrations of folate and para-aminobenzoic acid increases the 50% inhibitory concentrations of cycloguanil and pyrimethamine , as compared with the use of folate- and para-aminobenzoic acid-free RPMI medium.”
[Variability of in vitro activity of proguanil and cycloguanil on erythrocyte stages of Plasmodium falciparum as a function of culture conditions].“By disturbing folate metabolism in this fungus, pyrimethamine can inhibit ergosterol production.”
“Trimethoprim and pyrimethamine are weak competitive inhibitors of intestinal folate transport and folate absorption inhibition occurs at the site of membrane transport and appears to be unrelated to concurrent inhibition of DHFR activity in enterocytes.”
“Trimethoprim and pyrimethamine , inhibitors of dihydrofolate reductase (DHFR), cause folate deficiency in some patients.”
Competitive inhibition of folate absorption by dihydrofolate reductase inhibitors, trimethoprim and pyrimethamine.“The binding of folate analogs including folate, dihydrofolate, methotrexate, trimethoprim and pyrimethamine induce large Cotton effects.”
Circular dichroism studies of dihydrofolate reductase from a methotrexate-resistant strain of Escherichia coli B, MB 1428: ternary complexes.
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