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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Pyrazinamide
supplement:
Vitamin C
Research Papers that Mention the Interaction
“ Vit C synergizes with pyrazinamide , a unique TB drug with sterilizing activity, to kill dormant and replicating bacteria, negating any tolerance to rifampicin and isoniazid in combination treatment in both in-vitro and intracellular infection models.”
Multifaceted remodeling by vitamin C boosts sensitivity of Mycobacterium tuberculosis subpopulations to combination treatment by anti-tubercular drugs“The addition of vitamin C to monosuspensions of INH and PZA led to a marked decline in the amount of drug detectable and only in the case of RIF was > 90% of initial concentrations of the drug detectable after 28 days.”
“In this same study, vitamin C was found to exhibit synergism with pyrazinamide against M. tuberculosis through tackling the dormant organisms and inhibiting the development of rifampin-tolerant and isoniazid-tolerant persisters in intracellular infection models.”
Vitamin C and Mycobacterium tuberculosis Persisters
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