Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 19 days ago

Possible Interaction: Pyrazinamide and Vitamin C

supplement:

Vitamin C

Research Papers that Mention the Interaction

Vit C synergizes with pyrazinamide , a unique TB drug with sterilizing activity, to kill dormant and replicating bacteria, negating any tolerance to rifampicin and isoniazid in combination treatment in both in-vitro and intracellular infection models.
Redox biology  •  2018  |  View Paper
The addition of vitamin C to monosuspensions of INH and PZA led to a marked decline in the amount of drug detectable and only in the case of RIF was > 90% of initial concentrations of the drug detectable after 28 days.
The Pediatric infectious disease journal  •  1991  |  View Paper
In this same study, vitamin C was found to exhibit synergism with pyrazinamide against M. tuberculosis through tackling the dormant organisms and inhibiting the development of rifampin-tolerant and isoniazid-tolerant persisters in intracellular infection models.
Antimicrobial Agents and Chemotherapy  •  2018  |  View Paper