Possible Interaction: Pulmonary Surfactants and Vitamin E

“In membrane biophysics, Vitamin E is a linactant and a potent modulator of lateral phase separation that effectively reduces the line tension at the two-dimensional phase boundaries and thereby exponentially increases the surface viscosity of the pulmonary surfactant.”

“ Vitamin E significantly reduced the peroxidation level of surfactant in both cases.”

“ Vitamin E reduced the lipid peroxidation of this surfactant.”

“We speculate that addition of vitamin E to exogenous surfactant preparations may improve their resistance to LPO and make them more suitable for treatment of neonates with pneumonia.”

“Unlike thymalin, tocopheroli acetas is noted to augment the secretion of lysozyme, to decrease the activity of phospholipase A2, to improve the surface-active properties of the lung surfactant.”

“Administration of alpha-tocopherol during fasting reduced the disturbances in the pulmonary surfactant system of the animals and the degree of increased lipid peroxidation activity which indicates that the antioxidant protects the unsaturated fatty acids from oxidation.”

“Considering these results, surfactant micelles could be an important tool to increase the effectiveness of α-tocopherol.”

“Although the exact pathophysiology of vitamin E acetate‐induced lung injury is unknown, vitamin E acetate may lead to pulmonary lipid accumulation and/or interfere with surfactant functioning.”

“The time-resolved anisotropy studies suggest that incorporation of vitamin E and octanol into the surfactant aggregates results in slower and faster rotational motion of C153, respectively, compared to the micellar assemblies.”