Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: a month ago

Possible Interaction: Prostaglandin D2 and Methyl Nicotinate

Research Papers that Mention the Interaction

Here, we show that methylnicotinate induces significant PGD2 release from human mast cells and serotonin from human platelets.
Journal of Pharmacology and Experimental Therapeutics  •  2008  |  View Paper
We have shown that cutaneous vasodilatation induced by compounds such as sorbic acid and methylnicotinate is mediated by PGD2.
Journal of the American Academy of Dermatology  •  2001  |  View Paper
The … of PGD2 in response … topically applied methylnicotinate occurred in a dose-dependent manner over the concentration range of 10(-3) to 10(-1) M. The release of PGD2 was not accompanied by a release of histamine, suggesting that the release of PGD2 was not from the mast cell.
Topical … methylnicotinate (10(-1) M) to the forearms of human volunteers … in 58- to 122-times increases in levels of PGD2 and 25- to 33-times increases in levels of the metabolite of PGD2, 9 …,11 beta-PGF2, in blood drawn from the antecubital vein draining the treated sites.
The Journal of investigative dermatology  •  1992  |  View Paper