supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
drug:
Prostaglandin D2
supplement:
Methyl Nicotinate
Research Papers that Mention the Interaction
“Here, we show that methylnicotinate induces significant PGD2 release from human mast cells and serotonin from human platelets.”
Niacin-induced “Flush” Involves Release of Prostaglandin D2 from Mast Cells and Serotonin from Platelets: Evidence from Human Cells in Vitro and an Animal Model“We have shown that cutaneous vasodilatation induced by compounds such as sorbic acid and methylnicotinate is mediated by PGD2.”
“The … of PGD2 in response … topically applied methylnicotinate occurred in a dose-dependent manner over the concentration range of 10(-3) to 10(-1) M. The release of PGD2 was not accompanied by a release of histamine, suggesting that the release of PGD2 was not from the mast cell.”
“Topical … methylnicotinate (10(-1) M) to the forearms of human volunteers … in 58- to 122-times increases in levels of PGD2 and 25- to 33-times increases in levels of the metabolite of PGD2, 9 …,11 beta-PGF2, in blood drawn from the antecubital vein draining the treated sites.”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback