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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Propylthiouracil
supplement:
Serum Albumin, Human
Research Papers that Mention the Interaction
“Increasing the concentration of PTU from 0.8x10(-5) to 1.20x10(-4)M in the systems with HSA causes a decrease in fluorescence intensity of the protein excited with both 280 and 295nm wavelengths.”
Binding of 6-propyl-2-thiouracil to human serum albumin destabilized by chemical denaturants.“Interaction of propyluracil, thiouracil and propylthiouracil with HSA leads to the formation of complexes that show spectral shifts.”
“ Propylthiouracil is an antithyroid drug which is carried by the blood, thanks to its binding with human seroalbumin (HSA), and induces a structural alteration in HSA that changes the binding capability of other ligands.”
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