Possible Interaction: Propranolol and Yohimbine

“The lipid-mobilizing action of yohimbine was reinforced during physical exercise, completely suppressed after a meal and partially blocked by administration of propranolol (0.5 mg kg-1; 60 min before yohimbine).”

“Treatment with propranolol + yohimbine or BIBP-3226 significantly increased the temperature at which AR occurred (n = 4) or abolished it (n = 3).”

“Oral administration of propranolol (40 mg, 60 min before yohimbine) reduced the lipid-mobilizing action of yohimbine (70 percent) during the 60 min following its administration and then totally suppressed its effect until the end of the experimental period (180 min).”

“The β-adrenoceptor antagonist propranolol was able to prevent the above-mentioned effects of yohimbine , while pretreatment with the α1-adrenoceptor antagonist prazosin blocked only its facilitating effects on memory reconsolidation.”

“ Propranolol , but not prazosin, blocked reinstatement by both yohimbine and FS, suggesting the involvement of β-ARs.”

“On the other hand, yohimbine increased HR and diminished CO, and propranolol dramatically increased stroke volume by 30%.”

“Either diltiazem or yohimbine or propranolol or a combination of atropine, propranolol and yohimbine inhibited IPA-evoked insulin secretion significantly (p<0.03) from the pancreas of normal and diabetic rats.”

“Noradrenaline (1 nM-10 microM) induced a concentration-dependent vasodilatation, which was inhibited by concurrent treatment with yohimbine (10 microM) and propranolol (20 microM).”

“In the … of propranolol … yohimbine , the pressure curve was markedly shifted to the right by both the selective alpha-1A-antagonist 5-methylurapidil (3.3 nM), and by the alpha-1D antagonist BMY 7378 (0.1 microM) or SK&F 105854 (2 microM) in SHR but not in WKY.”

“ Propranolol (1 muM) antagonized all these effects, while preincubation with yohimbine and prazosin significantly enhanced NA action in cortical slices of duck and goose.”