Allen Institute for Artificial Intelligence logo

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 8 months ago

Possible Interaction: Propranolol and Vitamin K


Vitamin K

Research Papers that Mention the Interaction

For in vitro experiments using rat liver microsomes, the metabolism of propranolol was inhibited by vitamin K3.
For in vivo experiments, the area under the blood concentration-time curve and the maximum concentration of propranolol were markedly increased following intraportal infusion of propranolol with vitamin K3 , but intraportal administration of vitamin K3 had little effect on propranolol kinetics when propranolol was infused intravenously.
Thus, it was concluded that vitamin K3 inhibited the first-pass metabolism of propranolol.
Journal of pharmaceutical sciences  •  1985  |  View Paper