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Last Updated: 8 months ago

Possible Interaction: Propranolol and Vitamin C

supplement:

Vitamin C

Research Papers that Mention the Interaction

Compared to controls, vitamin C decreased the maximum concentration of propranolol from 463 to 334 nmol·l−1, and the area under the propranolol concentration-time curve (from 0 to 24 hours) from 3,13 to 1,96 μmol·l−1·h.
The heart-rate decreased less when propranolol was administered with ascorbic acid in comparison to control subjects, although this interaction has little biological importance.
European Journal of Clinical Pharmacology  •  2004  |  View Paper
It is reasonable to assume that the extremely small amounts of N-… should not represent a significant carcinogenic risk, but co-formulation of propranolol … ascorbic acid , which has been found to minimize the nitrosation reaction, might be useful … if minimal, contribution to the already existing exposure to genotoxic chemicals.
Carcinogenesis  •  1995  |  View Paper
The effect of l‐ascorbic acid is blocked by the nonselective serotonin antagonists methiothepin, clozapine, methysergide, and pizotifen, but not mesulergine, spiperone, MDL 72222, and dl‐propranolol , nor by the catecholaminergic receptor antagonists prazosin and S(−)‐sulpiride.
Journal of neurochemistry  •  1998  |  View Paper
Methylene blue, but not propranolol , blocked the endothelial augmentation of vascular relaxation to ascorbic acid.
Life sciences  •  1993  |  View Paper
Propranolol , verapamil and flunarizine had significant inhibitory effects on the peroxidation of rat liver microsomes in the presence of iron ions and ascorbic acid.
Biochemical pharmacology  •  1991  |  View Paper