Possible Interaction: Propranolol and Taurine

“Addition of paeonol and propranolol to TNF-α pre-treated cells had no significant effect on [3H]taurine uptake, but the addition of 10 mM taurine caused a reduction.”

“The inhibitory effects of taurine on the contractility of isolated jejunal segments were blocked by propranolol and L-NG-nitroarginine but not by phentolamine, suggesting that adrenergic β receptors and a nitric oxide relaxing mechanism were involved when isolated jejunal segments were in high contractile states.”

“ Propranolol , a nonspecific beta-adrenoceptor antagonist, enhanced the antiglycogenolytic effect of taurine and of all structurally related compounds capable of attenuating the outflow of adrenal catecholamines elicited by pyridoxal.”

“2) The depressor response of taurine in AHA could be antagonized by propranolol , but not by phentolamine. (”

“In propranolol (1 mg.kg-1) treated rabbits taurine significantly improved left ventricular dP/dtmax and cardiac output, which were previously depressed by propranolol.”

“This stimulation is blocked stereospecifically by L-propranolol , indicating that taurine is probably acting via beta-adrenergic receptors.”

“Isoproterenol (4 X 10(-7) M) stimulated the rate of taurine influx, but propranolol (1 X 10(-8) M) blocked this stimulation.”

“The inhibitory effects of taurine on the contractility of isolated jejunal segments were blocked by propranolol and L-NG-nitroarginine but not by phentolamine, suggesting that adrenergic β receptors and a nitric oxide relaxing mechanism were involved when isolated jejunal segments were in high contractile states.”