Possible Interaction: Propranolol and Phosphatidylethanolamine

“The lipophilic beta-adrenoceptor blocking drugs exaprolol and propranolol significantly decreased the incorporation of32P into phosphatidylethanolamine , phosphatidylcholine and phosphatidylinositol of isolated rat mast cells.”

“These potentiating and inhibitory actions of propranolol on the hydrolysis of PtdCho and PtdEtn were similarly elicited by sphingosine.”

“There was a reduction of phosphorylethanolamine methylation and a stimulation of that of phosphatidylethanolamine , and these effects were counteracted by the presence of 5 × 10−5M propranolol.”

“ Propranolol stimulated [3H]serine incorporation into phosphatidylserine and phosphatidylethanolamine , with no alteration in distribution of radioactivity among species; [3H]glycerol incorporation in phosphatidylethanolamine was inhibited, and its incorporation into phosphatidylserine was stimulated.”

“Addition of propranolol to kidney and liver minces caused reductions in the labeling of phosphatidylcholine and phosphatidylethanolamine and selective increases in the labeling of acidic lipids, restricted to phosphatidic acid in liver and phosphatidylinositol in kidney.”

“… general propranolol caused the following changes: (a) it stimulated by 2- to 6-fold the labelling of phosphatidic acid and phosphatidylinositol from [ 14 C]glucose, [ …-diglyceride, (c) it inhibited appreciably the incorporation of [ 14 C]glucose, [ 14 C]glycerol, [ 14 C]acetate and 32 Pi into phosphatidylcholine and phosphatidylethanoalmine.”

“At concentrations of 1–10 mM, propranolol and local anesthetics inhibited labeling of phosphatidylcholine and phosphatidylethanolamine by more than 90% and incorporation of 32Pi into other phospholipids to a smaller extent.”