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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Propranolol
supplement:
Calcium Supplement
Research Papers that Mention the Interaction
“ Propranolol , in the presence of calcium , causes marked K efflux from human red blood cells (high K, low Na).”
Cation specificity of propranolol‐induced changes in RBC membrane permeability: Comparative effects in human, dog and cat erythrocytes“Our results show that different β-blockers have differential effects on whole-cell currents and free Ca2+i release and that propranolol activates store-operated Ca2+i release via a mechanism that involves calcium-induced calcium release and putative downstream transducers such as IP3.”
“ Propranolol decreased the serum level of calcium through decreasing triiodothyronine level and through beta-receptor blocking effect as well as its direct effect on bone.”
“An increment of intracoronary Ca by 1.5mmol/1 enhanced the left ventricular contractility indexEmax (end-systolic maximum elastance) by 2.5 times before and after β-blockade with propranolol.”
Calcium equally increases the internal calcium recirculation fraction before and after β-blockade in canine left ventricles“Other experiments demonstrated that propranolol can enhance coronary arterial membrane permeability to calcium ions ; these observations suggest that propranolol might sensitize coronary vascular smooth muscle cells to calcium ions.”
“ Propranolol pretreatment (three days prior to the experiments) significantly reduced the myocardial enzyme release during calcium repletion in the minimal calcium paradox.”
“In skinned coronary arteries, Ca2+ -activated tension development was decreased by betaxolol and propranolol at concentrations of more than 10−5 and 10−4 M, respectively.”
“In PM, however, propranolol at a concentration of 0.1 mmol/l increased calcium uptake by the SR.”
“ Propranolol at concentrations of 0.3–1.0 mmol/l decreased calcium uptake by the SR but did not change caclium release in any of the three muscles.”
“We conclude that propranolol induces decreases in muscle contraction mainly by decreasing calcium uptake by the SR.”
“On the other hand, shivering activity measured at 4° C was less in CA than in WA, while propranolol administration eliminated the difference between these two groups by enhancing shivering in CA.”
“Enhancement of the contractile state with calcium increased Emax, and reduction of the contractile state with propranolol decreased Emax.”
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