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Discover Supplement-Drug Interactions

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Last Updated: 8 months ago

Possible Interaction: Propranolol and Ascorbate

supplement:

Ascorbate

Research Papers that Mention the Interaction

Analysis of intraocular tissue ascorbate indicated that propranolol inhibited ascorbate secretion at the 3000 microg dose, the highest dose examined in this study; this inhibition was not observed at the 750 microg or 1500 microg doses.
Propranolol (1500 microg) produced significant increases in aqueous humor ascorbate , this observation is consistent with a reduction in aqueous humor production (approximately 47%).
Experimental eye research  •  2000  |  View Paper
These results suggest that propranolol inhibits prolyl hydroxylase activity in vitro and in vivo at the site of action where an oxygen intermediate is formed from the interaction of ferrous iron and ascorbate.
Biochemical pharmacology  •  1980  |  View Paper