Possible Interaction: Propranolol and Adrenocorticotropic Hormone

“The ACTH plasma concentrations significantly increased in the placebo and the propranolol group, with significantly more pronounced changes in the propranolol-treated subjects compared to the placebo group.”

“5 The counterregulatory response of growth hormone, ACTH and cortisol was increased following metoprolol and propranolol but not after pindolol.”

“Concurrently, propranolol reduced heat tolerance, leading to an increased ACTH and Cortisol release in 3 of the subjects.”

“The propranolol infusion enhanced the stimulatory effect of hypoglycemia on ACTH , cortisol, and AVP secretion and also enhanced the stimulatory effect of CRH on ACTH and cortisol secretion.”

“An accidental observation led to the suspicion that propranolol (P) enhances the effect of exogenous ACTH on plasma cortisol.”

“We conclude that propranolol inhibits the maturational effects of adrenocorticotropin on the fetal lung, which implies that the mechanism of pulmonary maturation is not solely dependent on endogenous cortisol and must be mediated, at least in part, through adrenergic responses.”

“ Adrenocorticotrophic hormone caused a short-term induction of adipose tissue phosphopyruvate carboxylase, which could be blocked by propranolol.”

“While PGE1, Ko 592, and propranolol all inhibited the stimulatory effects of glucagon and ACTH on lipolysis in adipocytes, neither agent influenced the action of either hormone on glucose oxidation; the latter finding suggests that β-receptors do not mediate the stimulatory effects of these hormones on glucose oxidation.”

“Enzyme activity in the presence of ACTH was decreased by Ca2+, Na+, K+, and propranolol.”

“Combined intracerebroventricular injection of specific adrenergic blockers (α1‐antagonist, prazosin and ß‐antagonist, propranolol ) prevented the stimulation of the adrenocorticotropin release by hemorrhage.”