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Discover Supplement-Drug Interactions
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Last Updated: 3 months ago
drug:
Propafenone
supplement:
Quinidine
Research Papers that Mention the Interaction
“Low-dose quinidine may promote the efficacy of propafenone by inhibiting its degradation through the cytochrome P450 pathway (CYP2D6).”
“Of the 10 refractory patients, 7 were further controlled with a standard dose of propafenone plus quinidine (600 mg/day).”
Control of paroxysmal atrial fibrillation recurrence using combined administration of propafenone and quinidine.“In this study we tested the hypothesis that quinidine would enhance beta-blockade in extensive metabolizers receiving propafenone.”
“Throughout the study (follow-up, 199 ± 155 days), quinidine successfully inhibited CYP2D6: propafenone concentrations were 3 times higher in patients receiving quinidine (1033 ± 611 ng/mL vs 328 ± 229 ng/mL; P < .001).”
“In patients …, quinidine increased mean steady-state plasma propafenone concentrations more than two fold, from 408 +/- 351 (mean +/- s.d.) to 1096 +/- 644 ng ml-… 0.001), decreased 5-hydroxypropafenone concentrations from 242 +/- 196 to 125 +/- 97 ng ml-1 (P less than 0.02) and reduced propafenone oral …%.”
“Additive pharmacologic effect can occur when lidocaine, procainamide, and quinidine are combined with propafenone.”
“In 30 patients, the addition of propafenone resulted in a significant reduction of premature ventricular contraction (PVC) frequency compared to drug-free baseline (406 PVC/hr vs 33, p less than 0.001) and to procainamide or quinidine monotherapy (211 PVC/hr vs 27, p less than 0.01).”
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