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Last Updated: 3 months ago

Possible Interaction: Propafenone and Quinidine

supplement:

Quinidine

Research Papers that Mention the Interaction

Low-dose quinidine may promote the efficacy of propafenone by inhibiting its degradation through the cytochrome P450 pathway (CYP2D6).
Of the 10 refractory patients, 7 were further controlled with a standard dose of propafenone plus quinidine (600 mg/day).
The American journal of cardiology  •  2000  |  View Paper
In this study we tested the hypothesis that quinidine would enhance beta-blockade in extensive metabolizers receiving propafenone.
Clinical pharmacology and therapeutics  •  1994  |  View Paper
Throughout the study (follow-up, 199 ± 155 days), quinidine successfully inhibited CYP2D6: propafenone concentrations were 3 times higher in patients receiving quinidine (1033 ± 611 ng/mL vs 328 ± 229 ng/mL; P < .001).
Journal of clinical pharmacology  •  2012  |  View Paper
In patients …, quinidine increased mean steady-state plasma propafenone concentrations more than two fold, from 408 +/- 351 (mean +/- s.d.) to 1096 +/- 644 ng ml-… 0.001), decreased 5-hydroxypropafenone concentrations from 242 +/- 196 to 125 +/- 97 ng ml-1 (P less than 0.02) and reduced propafenone oral …%.
British journal of clinical pharmacology  •  1989  |  View Paper
Additive pharmacologic effect can occur when lidocaine, procainamide, and quinidine are combined with propafenone.
Clinical pharmacy  •  1988  |  View Paper
In 30 patients, the addition of propafenone resulted in a significant reduction of premature ventricular contraction (PVC) frequency compared to drug-free baseline (406 PVC/hr vs 33, p less than 0.001) and to procainamide or quinidine monotherapy (211 PVC/hr vs 27, p less than 0.01).
American heart journal  •  1987  |  View Paper