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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Prolinedithiocarbamate
drug:
Leptin
Research Papers that Mention the Interaction
“Transfection with insulin receptor substrate (IRS)-1 siRNA or dominant-negative mutant of p85 and Akt or pretreatment with phosphatidylinositol 3-kinase inhibitor (Ly294002 and wortmannin), Akt inhibitor, NF-kappaB inhibitor PDTC ) and NF-kappaB inhibitor peptide also inhibited the potentiating action of leptin.”
Leptin induces IL-8 expression via leptin receptor, IRS-1, PI3K, Akt cascade and promotion of NF-kappaB/p300 binding in human synovial fibroblasts.
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