Possible Interaction: Prolinedithiocarbamate and Gefitinib

“ Gefitinib combined with PDTC can inhibit P-IκBα production and NF-κB P-p50 and P-p65 activation to suppress the survival of residual H1650 cells and the generation of gefitinib-resistant cells.”

“In both the resistant and parental H1650 cells, gefitinib significantly lowered P-… expressions (P<0.05 or 0.01), and the combined treatment with gefitinib … PDTC significantly decreased the cell survival rate and further lowered the cytoplasmic and … P-p50 and P-p65 (P<0.01 or 0.01).”