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Last Updated: 8 months ago

Possible Interaction: Proline and Tryptophan

supplement:

Proline

supplement:

Tryptophan

Research Papers that Mention the Interaction

Tryptophan at 0.50% reduced total HCAs the most (0.92 ng/g, 93% inhibition), followed by 0.50% lysine (1.94 ng/g, 84% inhibition), while leucine (3.95 ng/g, 64% inhibition) and proline (4.71 ng/g, 56% inhibition) were less effective at 0.50%.
Journal of food science  •  2020  |  View Paper
Glycine, l-alanine, and l-tryptophan strongly inhibited l-proline uptake indicating that these amino acids also interact with the transport system.
Amino Acids  •  2012  |  View Paper
Although neither 5-hydroxy-l-tryptophan nor α-methyl-d l-tryptophan were able to elicit inward current in PAT2-expressing oocytes both reduced the current evoked by l-proline.
l-Proline uptake was inhibited by 5-hydroxy-l-tryptophan (IC50 1.6 ± 0.4 mM), α-methyl-d, l-tryptophan (3.5 ± 1.5 mM), l-tryptophan, 1-methyl-l-tryptophan and indole-3-propionic acid.
Biochimica et biophysica acta  •  2011  |  View Paper
Certain other amino acids (L-valine, L-alanine, L-methionine, L-phenylalanine, L-tryptophan and L-hydroxyproline) significantly stimulated proline uptake.
Comparative biochemistry and physiology. B, Comparative biochemistry  •  1992  |  View Paper
Glycine, lysine, arginine, valine, isoleucine, and tryptophan in the second position are (with N-terminal serine) strongly inhibitory, and proline completely blocks modification.
Biochemistry  •  1991  |  View Paper
A mixture of L‐pro and L‐tryptophan ( L‐trp ) at lower concentrations of each yielded increased inhibition, compared with the findings when each inhibitor was tested by itself.
Environmental and molecular mutagenesis  •  1988  |  View Paper
PRO acted as a stabilizer for the co-amorphous system, including NAP– TRP , through enhancing the molecular interactions in the form of hydrogen bonds between all three components in the mixture.
Pharmaceutics  •  2014  |  View Paper