Possible Interaction: Proline and Trehalose

“Two plausible mechanisms … discussed: (i) proline, … trehalose , could reduce partial unfolding of proteins and prevent membrane fusions in the larvae exposed to thermal stress (prior to freezing) or … in their ability to form supramolecular aggregates which probably bind partially unfolded proteins and inhibit their aggregation under increasing freeze dehydration.”

“Our results suggest that pre-incubation of Neuro-2a cells with trehalose and proline in combination provides cell protection along with alterations of ice structure in order to increase cell survival post-freezing.”

“Simultaneous accumulation of proline and trehalose in industrial baker's yeast also enhanced the fermentation ability in the frozen dough compared with the single accumulation of proline or trehalose.”

“Our results suggest that proline does not complement the function of trehalose , and that moderate expression of the PRO1 gene encoding γ-glutamyl kinase is important to stress tolerance of yeast cells.”

“However, correlation does not prove that these compounds are responsible for cold tolerance, and we outline further tests that could demonstrate a causal relationship between trehalose and proline and cold tolerance.”