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Discover Supplement-Drug Interactions

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Last Updated: 2 months ago

Possible Interaction: Proline and Threonine





Research Papers that Mention the Interaction

At both sites, cleavage occurs between proline and an O-linked glycosylated threonine , and deglycosylation of fXII prevents cleavage by CpaA. Consistent with this, mutant fXII (fXII-Thr309Lys) from patients with hereditary angioedema type III (HAEIII) is protected from CpaA inactivation.
mBio  •  2018  |  View Paper
It is likely that resistance to beta-elimination is due to very close proximity of proline to the glycosylated serine or threonine residues.
Carbohydrate research  •  2007  |  View Paper
Our data suggest strongly that the proline to threonine substitution may alter the protein folding or decrease the thermodynamic stability or solubility of the protein.
Journal of medical genetics  •  2003  |  View Paper
Whole-body glycine, proline , serine and cystine concentrations decreased (P < 0.05) as Thr was increased in the diet.
The British journal of nutrition  •  1997  |  View Paper
Analysis of the simulations shows that Ser or Thr can significantly modulate the deformation of the Pro.
Biophysical journal  •  2004  |  View Paper