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Last Updated: 8 months ago

Possible Interaction: Proline and Thioproline

supplement:

Proline

Research Papers that Mention the Interaction

The nitrosation of thioproline was estimated to be 1000-fold that of proline in the human body.
Cancer research  •  1988  |  View Paper
Separation of the influence of metabolism from … the use of proline analogues showed that thioproline … proline uptake by 80%, primarily by reducing the conversion of proline to glutamic acid, whereas 3,4-dehydroproline … to glutamic acid but principally appeared to alter the affinity of the transport system for proline.
Pediatric Research  •  1973  |  View Paper
The active part of the proline molecule is the α-imino group; substitutions in this group, such as 1-thiazolidine-4-carboxylic acid and glycylproline, annul the activity of proline.
Comparative and general pharmacology  •  1971  |  View Paper
Both analogs gave higher proline accumulation after 6 and 10 days (68 and 179% after 6 days with A2C at 25 and 50 μM, respectively, and 111% with T4C added at 100 μM).
Biotechnology Letters  •  2011  |  View Paper
T4C (1 millimolar) inhibited proline (10 millimolar) -dependent 0(2) uptake an average of 67%.
Plant physiology  •  1984  |  View Paper
Proline antagonizes the incorporation of " thioproline " into protein.
Proline antagonizes the incorporation of “ thioproline ” into protein.
The effectiveness of thioproline as a proline analogue is attributed to its ability to interfere with the utilization of proline for protein synthesis and to mimic proline in its function of being incorporated into proteins.
Journal of bacteriology  •  1966  |  View Paper
Hence, these experiments show that TZCA may be used as a competitive inhibitor to the incorporation of proline into ribosomes in a cell-free system.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine  •  1965  |  View Paper