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Last Updated: 8 months ago

Possible Interaction: Proline and Aspartate



Research Papers that Mention the Interaction

Infusion of the Glu transport inhibitor l‐trans‐pyrrolidine‐2,4‐dicarboxylic acid (200 µM) increased resting Glu and Asp levels by 300–500% without altering electrically stimulated changes in Glu and Asp concentration.
Journal of neurochemistry  •  1998  |  View Paper
7 The putative glutamate uptake current was further characterized; it was blocked by the competitive uptake blockers D‐aspartate (0.5 mM) and L‐trans‐pyrrolidine‐2,4‐dicarboxylic acid (PDC; 0.5 mM), and by replacement of sodium with lithium.
The Journal of physiology  •  1997  |  View Paper
PDC 10 mM perfusion produced an increase in the extracellular output of glutamate and aspartate , and a decrease in that of ascorbate.
British journal of pharmacology  •  1997  |  View Paper
In line with its enhancement of paired-pulse facilitation, 30 microM proline reduced both the K+-evoked release of glutamate and aspartate from CA1 slices and the release of glutamate and aspartate from CA1 synaptosomes evoked by 4-aminopyridine.
Brain Research  •  1997  |  View Paper
Indeed, the effects of proline on glycogen synthesis, lipogenesis and glutamate and aspartate content were faster.
The Biochemical journal  •  1991  |  View Paper
The reductions in the response threshold for aspartate by the replacements with serine, isoleucine, and proline were less than 1, about 2, and more than 5 orders of magnitude, respectively.
Journal of bacteriology  •  1990  |  View Paper
In this concentration range heroin increases the rate of accumulation in the free amino acid "pool" of aspartate , glutamate, and alanine, inhibits the accumulation of lysine and proline , and has no effect on the accumulation of five other amino acids tested.
Molecular pharmacology  •  1970  |  View Paper