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Last Updated: 2 months ago

Possible Interaction: Progestins and Tamoxifen

supplement:

Progestins

Research Papers that Mention the Interaction

Our results indicate that addition of the progestogen significantly alters the metabolism of tamoxifen over a six-month period.
Breast Cancer Research and Treatment  •  2005  |  View Paper
The hypothesis that 17 beta-estradiol or tamoxifen (TAM) can potentiate clinical response of endometrial cancer treated with progestin was tested in an ovariectomized nude mouse system, using a sex steroid receptor-positive and a receptor-negative human endometrial carcinoma.
Cancer research  •  1985  |  View Paper
Based on the finding that TAM induces functional PR, we predict that steroid receptor-positive endometrial carcinoma may show a greater response rate to combined, long-term treatment with TAM and progestin.
Cancer research  •  1984  |  View Paper
A higher risk in women receiving estrogen replacement therapy (ERT) or tamoxifen has been suspected, and remissions following treatment with progestins have been reported in case studies.
Gynecologic oncology  •  2006  |  View Paper
This relatively very low ER and PR content may be attributed to the antagonistic effect of progestogens on the "priming" estrogen-like effect of tamoxifen on the endometrium.
Gynecologic oncology  •  1997  |  View Paper
These data show that postmenopausal breast cancer patients who received progestogens for < or = 3 months, and who concomitantly took tamoxifen , had a uniform decidual reaction in all uteri.
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists  •  1996  |  View Paper
Adapted cells were growth inhibited by oestradiol, 4-hydroxy tamoxifen and medroxyprogesterone acetate, but despite elevated progesterone receptor expression the progestin was only marginally more inhibitory than in the parent line.
British Journal of Cancer  •  1990  |  View Paper
Current studies aim to relate RP levels to objective remissions of metastases after progestin therapy, and attempts are being made to increase RP with tamoxifen before treatment with progestins or assaying for RP.
Cancer  •  1981  |  View Paper
Combined treatment with tamoxifen and progestin effectively controlled human endometrial tumor growth in the nude mouse model.
Cancer letters  •  1992  |  View Paper
On the other hand, the addition of HRT containing progestins could also minimize the risk of endometrial cancer associated with tamoxifen.
The breast journal  •  2000  |  View Paper