Allen Institute for Artificial Intelligence logo

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 8 months ago

Possible Interaction: Progestins and Progesterone





Research Papers that Mention the Interaction

Since the intracellular effects on gene expression and cell signaling of steroids are mediated via intracellular steroid receptors, differential actions via the progesterone and other steroid receptors and their isoforms, are likely to be the major cause of differential intracellular actions of progestins.
Steroids  •  2011  |  View Paper
Pretreatment of cells with progesterone receptor-encoding adenovirus and progestin inhibited the development of s.c.
Molecular cancer therapeutics  •  2005  |  View Paper
The dual effect of progesterone and progestins on the cell cycle has been demonstrated, suggesting that according to the duration of administration, the same steroid can induce cells to enter the multiplication phase or to enter a resting state.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology  •  1999  |  View Paper
The largest study administering oral progestin using 300 mg micronized progesterone reported a 58.9% improvement in VMS (vs 23.5% in placebo group, n = 133), whereas the largest study using transdermal progesterone reported no improvement (n = 230).
Menopause  •  2020  |  View Paper
In luteal support, a Cochrane review reported that progestogens were associated with a higher rate of live births or ongoing pregnancy in the progesterone group (odds ratio 1.77, 95% confidence interval (CI) 1.09–2.86).
Climacteric : the journal of the International Menopause Society  •  2018  |  View Paper
The progesterone resistance is counteracted by progestins (Medroxyprogesterone acetate, Dienogest, Danazol, Levonorgestrel) or by Selective progesterone receptor modulators, a class of drugs under development.
European journal of obstetrics, gynecology, and reproductive biology  •  2017  |  View Paper
In the case of the other five reductases, gestagens had remarkably stronger inhibitory effects at a concentration of 25 μM ( progesterone : 66-88% inhibition; drospirenone: 26-87% inhibition) in comparison to estrogens (estradiol: 17-51% inhibition; ethinylestradiol: 14-79% inhibition) and androgens (14-78% inhibition).
Chemico-biological interactions  •  2017  |  View Paper
In theory, potent progestins could reactivate progesterone signaling that leads to follicle rupture, thereby impacting the effectiveness of UPA as EC.
Human reproduction  •  2015  |  View Paper
AOH exhibited a weak oestrogenic response when tested in the oestrogen responsive RGA and binding of progesterone to the progestagen receptor was shown to be synergistically increased in the presence of AOH.
Toxicology and applied pharmacology  •  2013  |  View Paper
Binding of progesterone to the progestagen receptor was shown to be synergistically increased in the presence of ZEN, α-ZOL or β-ZOL.
Toxicology letters  •  2011  |  View Paper
Show More