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Last Updated: 2 years ago

Possible Interaction: Progestins and Medroxyprogesterone Acetate

Research Papers that Mention the Interaction

Conclusions: Triglyceride levels during EPT every day with conventional doses of CEE and MPA increased more in overweight and obese postmenopausal women in association with increased estrogen levels.
Menopause  •  2005  |  View Paper
Effect-time studies indicate that injection of MPA and L. chuanxiong extract raised area-under-curve of progestogenic activity in sera by 8.2-fold (p<0.001) and 4.5-fold (p<0.01) respectively, compared to sera from rats administered vehicle only.
Life sciences  •  2006  |  View Paper
LH levels were suppressed after a 6-day progestin treatment in the medroxyprogesterone acetate + hMG and dydrogesterone +hMG groups, but there was a rebound of LH values in the progesterone +hMG group.
Frontiers in Endocrinology  •  2020  |  View Paper
CONCLUSIONS:The inhibitory effect of MPA on both basal and TNF&agr;-induced MMP-9 activity and gene expression in primary amnion cells demonstrate a possible mechanism by which progestins may prevent fetal membrane weakening leading to preterm premature rupture of membranes.
Anesthesia and analgesia  •  2015  |  View Paper
There is strong evidence that VTE risk is greater in women using medroxyprogesterone acetate compared with those receiving other progestins.
Climacteric : the journal of the International Menopause Society  •  2014  |  View Paper
With respect to the different pharmacological classes of progestogens , there is evidence for a deleterious effect of medroxyprogesterone acetate on VTE risk.
Maturitas  •  2011  |  View Paper
However, MPA antagonized the E2-induced significant reduction of MCP-1 synthesis, with the difference between both progestins being significant (p < 0.01).
Menopause  •  2002  |  View Paper
A significant decrease in TGF-alpha mRNA was apparent 6 h after exposure to MPA and a further decrease was seen 12-24 h after addition of the progestin.
Cancer research  •  1991  |  View Paper
The maximum was found at doses between 0.1-1 microM. The activities reduced steadily from the maximum stimulation to … 50% when the concentration of MPA increased from 1-30 microM. In addition, initial treatment of stroma cells with MPA (1-3 days) resulted … increase of activity after progestin ….
Endocrinology  •  1986  |  View Paper
Moreover, the E2DH activity was 2 to 5 times higher in epithelial cells cultured in the presence of the progestin medroxyprogesterone acetate , whereas it remained unchanged in fibroblasts cultured under the same conditions.
Endocrinology  •  1984  |  View Paper
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