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Discover Supplement-Drug Interactions

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Last Updated: 8 months ago

Possible Interaction: Progesterone and Zidovudine

supplement:

Progesterone

Research Papers that Mention the Interaction

However, the … concentrations of progesterone (10[-7] to …) and low-dose AZT (10[-8] to 10[-9] M) produced markedly synergistic inhibition of HIV-1 replication within acutely infected monocytic cell … additive inhibition of HIV-1 growth within chronically infected monocytic cells (U1) and primary placental macrophages (Hofbauer cells).
It is likely that progesterone suppresses LTR-driven gene expression through a nontranscriptional mechanism, and augments the efficacy of AZT through enhancement of its phosphorylation.
AIDS research and human retroviruses  •  1997  |  View Paper
Collectively, our results indicate that at clinically relevant concentrations (< or = 10 microM), ZDV significantly inhibits both the DNA synthesis of placental trophoblasts and their production of progesterone , while having a minimal effect on protein synthesis of both types of placental cells.
Journal of acquired immune deficiency syndromes  •  1993  |  View Paper