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Last Updated: 8 months ago

Possible Interaction: Progesterone and Verapamil

supplement:

Progesterone

Research Papers that Mention the Interaction

Synergy between the inhibitory effect of progesterone and the efflux pump inhibitors verapamil and 1-(1-naphthylmethyl)-piperazine is consistent with a role for efflux pumps in preventing progesterone-mediated inhibition of C. burnetii activity.
Infection and Immunity  •  2020  |  View Paper
The calcium channel blocker verapamil (200 μM) completely inhibited the transient rise in [Ca2+]i produced by progesterone , but 100 μM verapamil had only a partial effect.
Molecular reproduction and development  •  1994  |  View Paper
Since verapamil and progesterone are mutual inhibitors of P-glycoprotein ATPase stimulation in a non-competitive manner, these two molecules can also bind independently P-glycoprotein on separated sites.
This is confirmed here by the observation of a synergistic effect when mixtures of verapamil and progesterone are tested for the modulation of P-glycoprotein ATPase.
European journal of biochemistry  •  1997  |  View Paper
At high levels, progesterone and verapamil mutually enhanced each other's inhibitory action on the ATPase.
Biochimica et biophysica acta  •  1997  |  View Paper
E and E+P increased the potency of verapamil Ca2+ antagonism but none of the treatments modified reserpine direct inhibitory effects.
Acta physiologica, pharmacologica et therapeutica latinoamericana : organo de la Asociacion Latinoamericana de Ciencias Fisiologicas y [de] la Asociacion Latinoamericana de Farmacologia  •  1996  |  View Paper
As expected from their mutually non-exclusive interactions on P-gp, progesterone and verapamil when mixed induce a synergistic modulation of P-gp ATPase activity.
The Biochemical journal  •  1996  |  View Paper
The ability of progesterone , GABA, or muscimol to stimulate exocytosis was blocked by the Ca2+ channel antagonists verapamil or nifedipine.
Biology of reproduction  •  1995  |  View Paper
The calcium channel blocker, verapamil , also inhibited FPH-induced progesterone accumulation and GVDB in a dose-dependent manner, while having no effect on progesterone-induced meiotic resumption.
The Journal of experimental zoology  •  1986  |  View Paper
Verapamil , an agent which inhibits cellular uptake of calcium, attenuated cyclic AMP and progesterone production by both cell groups at similar concentrations.
Biology of reproduction  •  1984  |  View Paper
Although progesterone production was markedly increased by dibutyryl cyclic AMP, this was significantly lowered by an inhibitor of calcium uptake, verapamil.
American journal of obstetrics and gynecology  •  1983  |  View Paper
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