Possible Interaction: Progesterone and Valproic Acid

“ VPA affected luteal progesterone surge in 63.6% of cases.”

“Conclusions: The higher PASH prevalence in premenopausal woman (the majority of whom are actively taking oral contraceptive pills), in …% to 47% of men with gynecomastia and during pregnancy supports a hormonal etiology; the interaction between clonazepam, valproate , risperidone and progesterone could … the level of progesterone that could … PASH growth.”

“Alternatively, the increase in progesterone levels was linked to epilepsy and VPA further increased progesterone levels.”

“Serum concentrations of progesterone and dehydroepiandrosterone increased, and gonadotropins decreased, in men on VPA during the follow-up.”

“ Valproic acid blunted luteal Pg surge more frequently than other AED.”

“This result suggests that VPA increases mitochondrial cholesterol transport through a StAR-independent mechanism and is further supported by the fact that in isolated mitochondria VPA stimulates exogenous cholesterol metabolization to progesterone.”

“ VPA also reduces the cAMP-mediated increase of the StAR protein, mRNA levels, promoter activity and progesterone production.”

“All doses of VPA caused a marked inhibition of progesterone secretion after 48 hours while during long-term VPA exposure progesterone gradually increased demonstrating luteinization of cells.”

“ VPA treatment at 600 μM inhibited the progesterone production.”