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Last Updated: 8 months ago

Possible Interaction: Progesterone and Valproic Acid

Research Papers that Mention the Interaction

VPA affected luteal progesterone surge in 63.6% of cases.
Clinical neuropharmacology  •  1998  |  View Paper
Conclusions: The higher PASH prevalence in premenopausal woman (the majority of whom are actively taking oral contraceptive pills), in …% to 47% of men with gynecomastia and during pregnancy supports a hormonal etiology; the interaction between clonazepam, valproate , risperidone and progesterone could … the level of progesterone that could … PASH growth.
The American journal of case reports  •  2020  |  View Paper
Alternatively, the increase in progesterone levels was linked to epilepsy and VPA further increased progesterone levels.
The Journal of Steroid Biochemistry and Molecular Biology  •  2010  |  View Paper
Serum concentrations of progesterone and dehydroepiandrosterone increased, and gonadotropins decreased, in men on VPA during the follow-up.
Neurology  •  2001  |  View Paper
Valproic acid blunted luteal Pg surge more frequently than other AED.
Journal of endocrinological investigation  •  1997  |  View Paper
This result suggests that VPA increases mitochondrial cholesterol transport through a StAR-independent mechanism and is further supported by the fact that in isolated mitochondria VPA stimulates exogenous cholesterol metabolization to progesterone.
VPA also reduces the cAMP-mediated increase of the StAR protein, mRNA levels, promoter activity and progesterone production.
Toxicology in vitro : an international journal published in association with BIBRA  •  2011  |  View Paper
All doses of VPA caused a marked inhibition of progesterone secretion after 48 hours while during long-term VPA exposure progesterone gradually increased demonstrating luteinization of cells.
Seizure  •  2000  |  View Paper
VPA treatment at 600 μM inhibited the progesterone production.
The Journal of Steroid Biochemistry and Molecular Biology  •  2021  |  View Paper