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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Progesterone
Research Papers that Mention the Interaction
“However, Northern blotting analysis demonstrated that progesterone strongly down-regulated (up to 60-fold) the gene expression of urokinase plasminogen activator and increased (up to 5-fold) the expression of tissue-type plasminogen activator in these cells.”
Effect of progesterone on the invasive properties and tumor growth of progesterone receptor-transfected breast cancer cells MDA-MB-231.“The data also support a role for transcriptional regulation of uPA activity because treatment of cells with progesterone , hydrocortisone, or dexamethasone inhibited uPA activation on fibrin without affecting cellular aggregation.”
“ Progesterone , at supraphysiological concentrations, suppressed uPA secretion; this reaction was not altered by the progesterone receptor antagonist RU486 or the transcriptional inhibitor actinomycin D. It appears that progesterone exerted a direct biophysical effect on the plasma membrane manifested by an interference with shedding of uPA in exocytotic vesicles.”
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