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Discover Supplement-Drug Interactions

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Last Updated: 8 months ago

Possible Interaction: Progesterone and Urokinase-Type Plasminogen Activator

Research Papers that Mention the Interaction

However, Northern blotting analysis demonstrated that progesterone strongly down-regulated (up to 60-fold) the gene expression of urokinase plasminogen activator and increased (up to 5-fold) the expression of tissue-type plasminogen activator in these cells.
Clinical cancer research : an official journal of the American Association for Cancer Research  •  2001  |  View Paper
The data also support a role for transcriptional regulation of uPA activity because treatment of cells with progesterone , hydrocortisone, or dexamethasone inhibited uPA activation on fibrin without affecting cellular aggregation.
Journal of cellular physiology  •  1999  |  View Paper
Progesterone , at supraphysiological concentrations, suppressed uPA secretion; this reaction was not altered by the progesterone receptor antagonist RU486 or the transcriptional inhibitor actinomycin D. It appears that progesterone exerted a direct biophysical effect on the plasma membrane manifested by an interference with shedding of uPA in exocytotic vesicles.
The Journal of Steroid Biochemistry and Molecular Biology  •  2001  |  View Paper