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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Progesterone
drug:
Uridine Triacetate
Research Papers that Mention the Interaction
“In the human neuroblastoma SK-N-MC cell line, exogenous PROG (9300–93,000 pg/ml) had a significant effect on overall Tau and nuclear TDP-43 levels, reducing total Tau levels by ∼1.5-fold and increasing nuclear TDP-43 by 1.7- to 2.0-fold.”
Endogenous progesterone levels and frontotemporal dementia: modulation of TDP-43 and Tau levels in vitro and treatment of the A315T TARDBP mouse model“Previous studies have shown that progesterone modulates the activity of different kinases and the phosphorylation of Tau in the brain.”
Progesterone regulates the phosphorylation of protein phosphatases in the brain“Furthermore, progesterone administration resulted in an increase in the phosphorylation of two epitopes of Tau (Tau‐1 and PHF‐1) phosphorylated by GSK3β, but did not affect the phosphorylation of an epitope of Tau (Ser262) that is GSK3β insensitive.”
“In contrast, progesterone and its metabolites resulted in a significant decrease in the expression of Tau and GSK3β in the cerebellum.”
“The regulation of Tau expression and phosphorylation by progesterone may contribute to the hormonal regulation of cerebellar function by the modification of neuronal cytoskeleton.”
“Interestingly, progesterone significantly reduced tau hyperphosphorylation when administered both alone and in combination with estrogen.”
“The antiluteolytic effects of IFN tau are dependent on progesterone.”
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