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Discover Supplement-Drug Interactions

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Last Updated: 8 months ago

Possible Interaction: Progesterone and Uridine Triacetate

Research Papers that Mention the Interaction

In the human neuroblastoma SK-N-MC cell line, exogenous PROG (9300–93,000 pg/ml) had a significant effect on overall Tau and nuclear TDP-43 levels, reducing total Tau levels by ∼1.5-fold and increasing nuclear TDP-43 by 1.7- to 2.0-fold.
Disease Models & Mechanisms  •  2013  |  View Paper
Previous studies have shown that progesterone modulates the activity of different kinases and the phosphorylation of Tau in the brain.
Journal of neuroscience research  •  2010  |  View Paper
Furthermore, progesterone administration resulted in an increase in the phosphorylation of two epitopes of Tau (Tau‐1 and PHF‐1) phosphorylated by GSK3β, but did not affect the phosphorylation of an epitope of Tau (Ser262) that is GSK3β insensitive.
In contrast, progesterone and its metabolites resulted in a significant decrease in the expression of Tau and GSK3β in the cerebellum.
The regulation of Tau expression and phosphorylation by progesterone may contribute to the hormonal regulation of cerebellar function by the modification of neuronal cytoskeleton.
Developmental neurobiology  •  2007  |  View Paper
Interestingly, progesterone significantly reduced tau hyperphosphorylation when administered both alone and in combination with estrogen.
The Journal of Neuroscience  •  2007  |  View Paper
The antiluteolytic effects of IFN tau are dependent on progesterone.
Frontiers in bioscience : a journal and virtual library  •  2002  |  View Paper