Possible Interaction: Progesterone and Tyrosine

“Although the complete signaling pathway is not clear, progesterone activates phospholipase C and protein kinases and enhances tyrosine phosphorylation.”

“Both A23187 and progesterone markedly inhibited tyrosine phosphorylation of sperm STAT 4.”

“However, after incubation for 5 h, progesterone was able to enhance the tyrosine phosphorylation of a 95 kD sperm protein, which is phosphorylated progressively during capacitation in well-defined culture media.”

“These experiments revealed a selective increase in the tyrosine phosphorylation of a 94-kilodalton phosphoprotein in the presence of progesterone.”

“The results showed that the three concentrations (0.02 mmol/L, 0.2 mmol/L and 2mmol/L) of tyrosine inhibited progesterone secretion by trophoblast cells in vitro.”

“While progesterone secretion was suppressed by tyrosine , hCG secretion was unchanged.”

“Site-directed mutagenesis indicated that a tyrosine residue at position 464 of WT1 increased the 17α-hydroxylation of progesterone compared with an asparagine residue at that position of WT2.”

“… tyrosine phosphorylation … by progesterone at 10(-5) M. These results indicate that progesterone is implicated in insulin resistance during pregnancy by inhibiting the PI 3-kinase pathway … and 2) distal to Akt and 3) by suppressing the PI 3-kinase-independent pathway of TC10 activation by affecting Cbl phosphorylation.”

“In contrast, progesterone significantly increased the levels of PP2A phosphorylated in tyrosine 307 in the hippocampus and the cerebellum and significantly decreased the levels of PTEN phosphorylated in serine 380 in the hypothalamus and in the hippocampus compared with control values.”

“ Tyrosine 170 mg.kg-1 on day 6-10 of gestation significantly decreased the concentration of serum progesterone in early pregnant mice.”

“hCG, cAMP and progesterone all could significantly increase the content of tyrosine in the suspensions, suggesting the release of "endogenous tyrosine".”