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“ Tryptophan on the other hand could block the progesterone (10 mumol/L) induced depolarization but had no effect on the db-cAMP induced hyperpolarization.”
Journal of steroid biochemistry • 1977 | View Paper
“Various substitutions for highly conserved glycines at positions 111 and 117 and tryptophan at position 120 strongly decreased the lauric acid hydroxylase activity of P450 2C2 and C2MstC1 and the progesterone hydroxylase activity of C2MstC1.”