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Discover Supplement-Drug Interactions

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Last Updated: 8 months ago

Possible Interaction: Progesterone and Trypsin





Research Papers that Mention the Interaction

It was found that progesterone has increased cell resistance to trypsin digestion and increased cell attachment to extracellular matrix proteins, especially laminin and fibronectin.
Clinical cancer research : an official journal of the American Association for Cancer Research  •  2001  |  View Paper
These results show that trypsin and chymotrypsin inhibitors are effective in blocking the acrosome reaction induced by progesterone in canine; in addition, they suggest the participation of respective proteases in the AR process in this species.
Reproduction in domestic animals = Zuchthygiene  •  2010  |  View Paper
On the other hand, both 17β‐estradiol and progesterone dose‐dependently enhanced the contractile response to trypsin.
British journal of pharmacology  •  2005  |  View Paper
In addition, a sperm trypsin like protease may be part of the mechanism by which progesterone stimulates AR.
Molecular reproduction and development  •  1996  |  View Paper
Progesterone binding activity was directly proportional to the sample concentration, was significantly reduced by trypsin digestion, and was pH-dependent and temperature-sensitive.
Biology of reproduction  •  1993  |  View Paper
Trypsin pretreatment of microsomes inhibited the esterification of both sterols and a similar dose-dependent inhibition was produced by addition of progesterone and several androgens.
Biochimica et biophysica acta  •  1983  |  View Paper