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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
supplement:
Progesterone
drug:
Troglitazone
Research Papers that Mention the Interaction
“OBJECTIVE Troglitazone is a potent inhibitor of progesterone release from porcine granulosa cells.”
Troglitazone is a competitive inhibitor of 3beta-hydroxysteroid dehydrogenase enzyme in the ovary.“ Troglitazone inhibited progesterone production in a dose- and time-dependent manner (earliest effects at 4 h, maximum at 24 h) without affecting cell viability.”
Troglitazone inhibits progesterone production in porcine granulosa cells.“ Troglitazone inhibited progesterone production in a doseand time-dependent manner (earliest effects at 4 h, maximum at 24 h) without affecting cell viability.”
“We found that troglitazone inhibits progesterone production in granulosa cells by inhibiting the activity of 3bhydroxysteroid dehydrogenase (3b-HSD).”
Troglitazone Inhibits Progesterone Production in Porcine Granulosa Cells* * This work was supported by a grant from the Sankyo Corporation (to R.J.U. and A.G.) and NIH Grant RO1-CA45181 (to M.N.).
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