Possible Interaction: Progesterone and Trilostane

“ Progesterone and estradiol production was significantly reduced in the women receiving trilostane , with maintenance of diurnal cortisol variation.”

“ Trilostane is a 3beta-hydroxysteroid dehydrogenase inhibitor which reduces progesterone production.”

“In conclusion, trilostane treatment was effective in decreasing plasma progesterone concentration in bitches during the luteal phase, but the dose regimen used in this study produced less clear-cut inhibition of ovarian steroidogenesis than have other strategies to decrease plasma progesterone concentration.”

“ Trilostane also caused a significant decrease in plasma progesterone concentration.”

“Inhibition of endogenous progesterone production with trilostane or knockdown of PRA expression with small interfering RNA significantly enhanced the glucocorticoid receptor (GR)-mediated COX-2 induction by cortisol, whereas overexpression of PRA attenuated the induction by cortisol.”

“Inhibition of endogenous progesterone production with trilostane enhanced 11beta-HSD2 activity.”

“In study 2, trilostane treatment decreased (P < 0.05) progesterone concentrations by 91% on day 1 of culture but had no effect on VEGF concentrations on any day.”

“ Trilostane afforded reduction of plasma levels of aldosterone, progesterone , deoxycorticosterone, 17-OH progesterone, cortisol, delta 4-androstenedione, and urinary excretion of 17-hydroxycorticosteroid.”

“In pregnant ewes, inhibition of progesterone production by trilostane during the day 5 to 16 period prevented the rise in progesterone concentrations and led to a significant increase of FOXL2 expression in caruncles compared with the control group (1.4-fold, p < 0.05).”

“In the FST, a co-treatment with trilostane facilitated DHEAS (5-20 mg/kg) antidepressant activity, but showed only an additive, not facilitative, effect with PREGS (10-40 mg/kg), PROG (10-40 mg/kg) or allopregnanolone (ALLO, 1-8 mg/kg).”

“ Trilostane (25 mg/kg) decreased hippocampus PROG contents and paradoxically increased circulating PROG levels.”

“ Trilostane caused a potent inhibition of the rate of conversion of PREG to PROG.”

“ Trilostane , a competitive inhibitor of the 3beta-HSD caused a potent inhibition of the rate of conversion of PREG to PROG (IC50 = 4.06 +/- 2.58 microm).”