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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Progesterone
drug:
Trifluoperazine
Research Papers that Mention the Interaction
“DDE is an inhibitor of calmodulin: other calmodulin inhibitors as calmidazolium and trifluoperazin also reduced the binding of progesterone in similar concentrations.”
The effects of DDE, PCB and chlordane on the binding of progesterone to its cytoplasmic receptor in the eggshell gland mucosa of birds and the endometrium of mammalian uterus.“Omission of Ca++ in the medium, or addition of a Ca++ channel blocker (D-600, 10(-4) M), of a calmodulin inhibitor trifluoperazine , 30 microM) or of a calmodulin-dependent tubulin kinase inhibitor (phenytoin, 50 microM), antagonized the stimulatory effect of progesterone.”
“Two inhibitors of the calcium-dependent regulatory protein, calmodulin trifluoperazine , 40 microM and 1[bis-(p-chlorophenyl)methyl] 3-[2,4-dichloro-beta-(2,4- dichlorobenzyloxy )-phenethyl]imidazolium chloride, ( R24571 ) 20 microM] significantly inhibited both cyclic AMP and progesterone production elicited by these stimulatory agents.”
“FSH-stimulated production of cyclic AMP and progesterone and dibutyryl cyclic AMP-induced progesterone biosynthesis were all significantly reduced by trifluoperazine , a specific inhibitor of calmodulin.”
“In addition, the susceptibility of progesterone biosynthesis to inhibition by trifluoperazine suggests a possible role for calmodulin in the ovary.”
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