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Last Updated: 9 months ago

Possible Interaction: Progesterone and Trifluoperazine

Research Papers that Mention the Interaction

DDE is an inhibitor of calmodulin: other calmodulin inhibitors as calmidazolium and trifluoperazin also reduced the binding of progesterone in similar concentrations.
Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology  •  1988  |  View Paper
Omission of Ca++ in the medium, or addition of a Ca++ channel blocker (D-600, 10(-4) M), of a calmodulin inhibitor trifluoperazine , 30 microM) or of a calmodulin-dependent tubulin kinase inhibitor (phenytoin, 50 microM), antagonized the stimulatory effect of progesterone.
Neuroendocrinology  •  1985  |  View Paper
Two inhibitors of the calcium-dependent regulatory protein, calmodulin trifluoperazine , 40 microM and 1[bis-(p-chlorophenyl)methyl] 3-[2,4-dichloro-beta-(2,4- dichlorobenzyloxy )-phenethyl]imidazolium chloride, ( R24571 ) 20 microM] significantly inhibited both cyclic AMP and progesterone production elicited by these stimulatory agents.
Biology of reproduction  •  1984  |  View Paper
FSH-stimulated production of cyclic AMP and progesterone and dibutyryl cyclic AMP-induced progesterone biosynthesis were all significantly reduced by trifluoperazine , a specific inhibitor of calmodulin.
American journal of obstetrics and gynecology  •  1983  |  View Paper
In addition, the susceptibility of progesterone biosynthesis to inhibition by trifluoperazine suggests a possible role for calmodulin in the ovary.
The Biochemical journal  •  1982  |  View Paper