Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
“ Progesterone secretion by both JEG-3 and BeWo cell lines were stimulated at high concentrations of RA (1 x 10(-6], whereas progesterone secretion by JAR cells was not stimulated.”
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme • 1998 | View Paper
“The antiproliferative effect of retinoid may also be direct or indirect by virtue of down-regulation of the receptors for one of the mitogenic hormones, possibly progesterone.”
Journal of reproduction and fertility • 1988 | View Paper
“ Basal progesterone and its accumulation in response to human low density lipoprotein were significantly higher in cells preincubated with retinoids than in the control cells.”
“Surprisingly, the deleterious concentrations of retinoic acid increased progesterone accumulation significantly higher than the medium control value.”
“In addition, our results showed that both E/P and retinoid treatments resulted in increased RARE and p53 gene activity.”
“Our studies also demonstrate that the potency of retinoids on cell growth inhibition may be increased through combination of estrogen and progesterone treatment.”
“The growth inhibitory effects of retinoids were further increased in the presence of E/P , suggesting their effects are additive.”
“These inhibitions on telomerase activity by retinoids were potentiated by co-treatment with E/P , and correlated well with their observed growth inhibitory effects.”
“We further demonstrated that p53 and p21 protein expression were induced following the E/P and retinoid treatments.”