Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 8 months ago

Possible Interaction: Progesterone and Tretinoin

supplement:

Progesterone

supplement:

Tretinoin

Research Papers that Mention the Interaction

In addition, ATRA also induced the de novo synthesis of neurosteroids such as pregnenolone and progesterone.
Journal of biochemistry  •  2009  |  View Paper
Progesterone secretion by both JEG-3 and BeWo cell lines were stimulated at high concentrations of RA (1 x 10(-6], whereas progesterone secretion by JAR cells was not stimulated.
Endocrinology  •  1991  |  View Paper
Retinol significantly decreased both hormone levels, however retinoic acid decreased the progesterone level only.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme  •  1998  |  View Paper
The antiproliferative effect of retinoid may also be direct or indirect by virtue of down-regulation of the receptors for one of the mitogenic hormones, possibly progesterone.
Endocrinology  •  1995  |  View Paper
Results showed that both retinol and retinoic acid greatly increased progesterone production in this cloned cell line.
Biochemistry international  •  1990  |  View Paper
As compared to their respective controls, all concentrations of retinoic acid and beta-carotene increased progesterone content in the media.
Journal of reproduction and fertility  •  1988  |  View Paper
Basal progesterone and its accumulation in response to human low density lipoprotein were significantly higher in cells preincubated with retinoids than in the control cells.
Surprisingly, the deleterious concentrations of retinoic acid increased progesterone accumulation significantly higher than the medium control value.
Endocrinology  •  1987  |  View Paper
Rates of secretion of progesterone and 20alpha-hydroxypregn-4-en-3-one, both on days 9 and 15, were lower for the rats given retinoic acid.
The Biochemical journal  •  1971  |  View Paper
In addition, our results showed that both E/P and retinoid treatments resulted in increased RARE and p53 gene activity.
Our studies also demonstrate that the potency of retinoids on cell growth inhibition may be increased through combination of estrogen and progesterone treatment.
The growth inhibitory effects of retinoids were further increased in the presence of E/P , suggesting their effects are additive.
These inhibitions on telomerase activity by retinoids were potentiated by co-treatment with E/P , and correlated well with their observed growth inhibitory effects.
We further demonstrated that p53 and p21 protein expression were induced following the E/P and retinoid treatments.
Cancer Cell International  •  2005  |  View Paper