supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 8 months ago
supplement:
Progesterone
supplement:
Tretinoin
Research Papers that Mention the Interaction
“In addition, ATRA also induced the de novo synthesis of neurosteroids such as pregnenolone and progesterone.”
Retinoic acids induce neurosteroid biosynthesis in human glial GI-1 Cells via the induction of steroidogenic genes.“ Progesterone secretion by both JEG-3 and BeWo cell lines were stimulated at high concentrations of RA (1 x 10(-6], whereas progesterone secretion by JAR cells was not stimulated.”
“Retinol significantly decreased both hormone levels, however retinoic acid decreased the progesterone level only.”
Testosterone and progesterone level alterations in the adult rat after retinoid (retinol or retinoic acid) treatment (imprinting) in neonatal or adolescent age.“The antiproliferative effect of retinoid may also be direct or indirect by virtue of down-regulation of the receptors for one of the mitogenic hormones, possibly progesterone.”
“Results showed that both retinol and retinoic acid greatly increased progesterone production in this cloned cell line.”
“As compared to their respective controls, all concentrations of retinoic acid and beta-carotene increased progesterone content in the media.”
“ Basal progesterone and its accumulation in response to human low density lipoprotein were significantly higher in cells preincubated with retinoids than in the control cells.”
“Surprisingly, the deleterious concentrations of retinoic acid increased progesterone accumulation significantly higher than the medium control value.”
“Rates of secretion of progesterone and 20alpha-hydroxypregn-4-en-3-one, both on days 9 and 15, were lower for the rats given retinoic acid.”
“In addition, our results showed that both E/P and retinoid treatments resulted in increased RARE and p53 gene activity.”
“Our studies also demonstrate that the potency of retinoids on cell growth inhibition may be increased through combination of estrogen and progesterone treatment.”
“The growth inhibitory effects of retinoids were further increased in the presence of E/P , suggesting their effects are additive.”
“These inhibitions on telomerase activity by retinoids were potentiated by co-treatment with E/P , and correlated well with their observed growth inhibitory effects.”
“We further demonstrated that p53 and p21 protein expression were induced following the E/P and retinoid treatments.”
Activation of p53, inhibition of telomerase activity and induction of estrogen receptor beta are associated with the anti-growth effects of combination of ovarian hormones and retinoids in immortalized human mammary epithelial cells
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback