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Discover Supplement-Drug Interactions

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Last Updated: 3 years ago

Possible Interaction: Progesterone and Tibolone

supplement:

Progesterone

drug:

Tibolone

Research Papers that Mention the Interaction

“ Tibolone and the Delta4-isomer bind and activate progesterone and androgen receptors whereas 3alpha-OH and 3beta-OH tibolone activate the estrogen receptors.”
Regulation of SULT1E1 expression in Ishikawa adenocarcinoma cells by tibolone
Steroids  •  2006  |  View Paper
“Both E2 + NETA and tibolone treatments induced an increase in progesterone levels (p < 0.05) after 1 year of therapy.”
Tibolone, transdermal estradiol or oral estrogen–progestin therapies: Effects on circulating allopregnanolone, cortisol and dehydroepiandrosterone levels
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology  •  2005  |  View Paper
“In conclusion, tibolone inhibits SMC growth and MAPK phosphorylation via both its estrogenic and progestogenic metabolites, and these inhibitory effects involve both progesterone and ERs.”
Tibolone and its metabolites induce antimitogenesis in human coronary artery smooth muscle cells: role of estrogen, progesterone, and androgen receptors.
The Journal of clinical endocrinology and metabolism  •  2004  |  View Paper