Possible Interaction: Progesterone and Theophylline

“These data suggest the influence of progesterone on theophylline and prolactin stimulated Ca2+ exit from intracellular stores of pig oocytes.”

“Effects of theophylline and progesterone on avidin synthesis in oviduct culture were synergistic.”

“The results suggest that theophylline can mimic the action of progesterone on avidin production, and that cyclic nucleotides may have a role in the regulation of avidin synthesis.”

“Simultaneous addition of progesterone and either dibutyryl cyclic AMP or theophylline results in synergistic inhibition of collagenase production.”

“At submaximally stimulating doses of 0LH or bLH and dibutyryl cyclic AMP, theophylline and 3-isobutyl-1-methylxanthine (MIX) potentiated progesterone production, while at maximally stimulating doses of agonists both theophylline and MIX inhibited steroidogenesis.”

“ Theophylline and papaverine do not increase endogenous cyclic AMP levels in oocytes but do block the decrease of cyclic AMP levels observed 3 hr after progesterone treatment.”

“This report presents evidence that exposure of prophase-arrested oocytes to progesterone lowers intracellular cyclic AMP and cyclic GMP levels, that theophylline inhibits one component of this response, and that periodic cyclic nucleotide fluctuations occur during the subsequent maturation divisions.”

“ Theophylline , a competitive inhibitor of cAMP phosphodiesterase, inhibits the maturation of oocytes previously exposed to progesterone.”

“When non-inhibitory concentrations of … (1 · 10 −4 M) or theophylline (1 · 10 −4 M) are added to … a non-inhibitory concentration of either progesterone (5 · 10 −6 M) or the potent progesterone analogue Provera (1 · 10 −… ability of the tissue to produce collagenase is decreased by 40–70%.”