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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Progesterone
Research Papers that Mention the Interaction
“They identify the molecular target by which THC affects sexual behavior, and unveil a remarkable operative cross talk mechanism between THC and the progesterone and dopamine signaling pathways, which were already known to play a central role in reproductive behavior.”
How might cannabinoids influence sexual behavior?“Our results revealed that the facilitatory effect of THC was inhibited by antagonists to both progesterone and dopamine D(1) receptors.”
Progesterone receptor and dopamine receptors are required in Delta 9-tetrahydrocannabinol modulation of sexual receptivity in female rats.“FSH treatment increased progesterone and estrogen biosynthesis, whereas concomitant treatment with THC led to a dose-dependent inhibition of the FSH-stimulated accumulation of progesterone and estrogen with ED50 values of 3.5 +/- 0.3 X 10(-7) and 1.8 +/- 0.2 X 10(-6) M, respectively.”
“This same dose of THC blocks both the estrogen and progesterone mediated positive feed-back release of LH.”
“Studies on experimental animals have indicated that THC can cause a decline in the pituitary hormones follicle stimulating hormone, luteinizing hormone, and prolactin, and in the steroids progesterone , estrogen, and androgens.”
[Review and update: marijuana and reproduction].
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